FOR PROVIDERS

HelioLiver™ LDT

A multi-analyte blood test combining cell-free DNA (cfDNA) methylation patterns and protein tumor markers.

available now for CLINICAL use

A Breakthrough in Liver Cancer Testing

HelioLiver LDT is a new, non-invasive blood test that detects DNA markers associated with a higher risk of hepatocellular carcinoma (HCC). HelioLiver LDT can be done using a simple blood draw during a regular physician visit, eliminating the need for a separate appointment at an imaging lab.

Powered by advanced AI and machine learning, HelioLiver LDT is the first blood test to use methylation to detect early-stage liver cancer, offering new hope to patients and healthcare providers. Early detection opens up more curative treatment options, improving outcomes for all.

Elevating the Standard of Care

Today, less than 20% of at-risk patients receive recommended testing for HCC

Guidelines recommend routine HCC surveillance for cirrhosis, typically with an ultrasound every six months. However, fewer than 20% of patients receive the recommended testing.

Why?

Patient-Reported Barriers

Scheduling process - requires a separate visit, potentially at a different center
Socioeconomic reasons - a separate appointment may mean another day off
Long wait times
Access to a nearby imaging lab
Uncertainty of where to get surveillance

HelioLiver was designed to improve both patient adherence and sensitivity for small lesions

	HELIOLIVER	ULTRASOUND
Sensitivity for Lesions <2cm	29%	0%
Sensitivity for Stage 1 HCC	44%	11%
Turnaround Time	10-14 days	~20 days
Surveillance Method	Blood Draw (~5 min)	Imaging (30-60 min)
Scheduling	Same Day at Doctor’s Office	Separate Appointment at Imaging Center
Analysis Method	Analysis of Liver Serum Levels + Methylation Signals from DNA	Visual Scan

Learn how HelioLiver's methylation approach can overcome obstacles with the current surveillance landscape for liver cancer

Presenter: Shivani Mahajan, Head of Computational Science at Helio Genomics

Length: 5:19 minutes

Direct Link: YouTube

The HelioLiver LDT Workflow

Ordering the HelioLiver test is simple and straightforward

Order Test

Each provider is set up with an ordering process fit for their office (via TRF or EMR)

Collect Sample

The HelioLiver Collection Kit provides materials to collect and pack serum and plasma samples from each patient

Ship it back

A prepaid, return shipping label is included in each test kit

Wait for Analysis

Average turnaround time is 10-14 days for each sample

Receive Report

A “normal” or “abnormal” result is given to indicate the likelihood of HCC

Medical personnel taking blood from patient

Driving Patient Adherence

Routine surveillance is critical for patients to catch cancer early before it spreads. We partner with physicians to help ensure patients maintain the recommended schedule for liver cancer testing.

Testing intervals for HCC surveillance consider the tumor doubling time and the cost of the surveillance test. Guidelines recommend patients at high risk for HCC, such as cirrhosis, undergo surveillance every 6 months

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